"Познание начинается с удивления" (Аристотель)
Новое в науке на 2026-10-22
Genome-wide association analyses of liver triglyceride content in 71,488 UK Biobank participants identify 60 independent loci and yield polygenic scores correlated with higher risk of cirrhosis and hepatocellular carcinoma.
2026-10-21
GISMO and GISMO-mis are new metrics of evolutionary constraint developed across 462 mammalian species. These metrics provide complementary measures of gene essentiality and improve prioritization of human disease genes.
2026-10-20
This study introduces Manc-COJO, a method for detecting independent genetic associations by integrating data from multiple ancestries, reducing false positives and enabling fast, flexible analyses across diverse populations.
2026-10-20
A Mayo Clinic-led study has shown how to detect a broad range of DNA mutations in noncancerous human tissues and across the genome. The analysis,...
2026-10-15
Kjer-Hansen et al. show that alternative splicing reshapes how proteins interact and where they localize in cells, with tiny microexons making a disproportionate contribution to protein organization and cellular function.
2026-10-14
Living human cells appear to hold the local movement of their DNA at a remarkably steady level through most of the cell cycle, only dialing it up...
2026-10-14
Klose et al. provide structural insights into a supercomplex between the EMC and Spf1 that brings together cellular machines for membrane protein insertion and extraction into a single entity, providing a framework for integrated membrane protein quality control.
2026-10-13
Most GWAS loci fall in regions that control gene expression rather than in the genes themselves, and linking those variants to eQTL and sQTL signals...
2026-10-13
Studying how chromatin changes requires capturing molecular movements and interactions that are difficult to resolve experimentally. Now, an...
2026-10-09
Spatial transcriptomics (ST) shows which genes are active and where within a tissue, while spatial metabolomics (SM) maps the location of...
2026-09-29
