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"Жизнь коротка, наука -- бесконечна" (Гиппократ)
Новое в науке на 2026-08-02

Cumulative transcription factor binding and p300-mediated histone acetylation drive enhancer activation frequency

This study uses single-molecule footprinting to quantify chromatin accessibility at enhancers and promoters in mouse embryonic stem cells and to dissect the contributions of transcription factor binding and chromatin context.

2026-07-31

Gene mutant dosage is associated with prognosis and metastatic tropism in 60,000 clinical cancer samples

The authors present INCOMMON, an open-source Bayesian inference tool that determines the multiplicity and copy number of driver mutations from tumor sequencing datasets.

2026-07-31

Factors modulating the assembly of human β2-adrenergic receptor–β-arrestin complexes

Wilhelm, Pluhackova and colleagues show how ligand binding, receptor phosphorylation and membrane interactions, including PIP2, drive the assembly of human β2-adrenergic receptor–β-arrestin complexes, providing insight into structural mechanisms regulating GPCR signaling.

2026-07-31

New Genomic Method Uncovers Ancient Hominin DNA

UC Berkeley researchers have developed a new computational technique that identifies regions of the human genome inherited from previously unknown...

2026-07-31

Protein thiol alterations drive pathologic liquid–liquid phase separation in the aging brain

Vignane et al. show that age-related protein oxidation disrupts normal brain protein organization, promoting harmful condensates and aggregation linked to neurodegeneration, whereas hydrogen sulfide-driven persulfidation counteracts these effects.

2026-07-30

Multi-ancestry genome-wide association analyses provide insights into the genetic basis of Hashimoto’s thyroiditis

Multi-ancestry genome-wide association analyses of Hashimoto’s thyroiditis identify new risk loci and highlight shared genetic architecture with other autoimmune diseases and pleiotropic effects on clinical outcomes.

2026-07-29

Paired mutation calling and spatial transcriptomics identify cellular neighborhoods associated with the neoplastic outcome of mouse colitis

This study uses a mouse model of inflammatory bowel disease to explore how mutations and cellular context combine to drive the transition to malignancy.

2026-07-28

Study Captures the First Moments of DNA Replication

Researchers at the MRC Laboratory of Medical Sciences (LMS) and collaborators have identified one of the earliest steps in DNA replication: the...

2026-07-24

Chemotherapy Leaves Detectable DNA Signatures in Childhood Tumors

A study (https://www.nature.com/articles/s41586-026-10803-1) led by The Hospital for Sick Children (SickKids), published in Nature, found that nearly...

2026-07-23

Single-Cell Atlases Skew Toward European Ancestry, Analysis Finds

A study led by researchers at the Icahn School of Medicine at Mount Sinai finds that single-cell atlases do not fairly represent the world’...

2026-07-20

UC San Diego Bioengineers Map Gene Function in Human Stem Cells

Bioengineers at the University of California San Diego have developed a genome-scale reference map showing how individual genes control the functions...

2026-07-13