"Жизнь коротка, наука -- бесконечна" (Гиппократ)
Новое в науке на 2026-04-09
Biallelic variants in RNU4-2 cause a recessive neurodevelopmental disorder that is phenotypically and molecularly distinct from dominant ReNU syndrome and associated with reduced RNU4-2 transcript levels, consistent with a loss-of-function mechanism.
2026-04-08
Sugar porters are textbook examples of how transport activity is described by Michaelis–Menten kinetics. Here, using saturation transfer difference nuclear magnetic resonance spectroscopy, Ahn et al. conclude that the fully occluded state of a sugar transporter is analogous to the transition state in soluble enzymes.
2026-04-08
Zehr et al. revealed the 2.7-Å cryo-electron microscopy reconstruction of human microtubules in situ in the axon of induced pluripotent stem cell (iPS cell)-derived neurons. It shows an expanded microtubule lattice yet bound to GDP, in contrast to the compacted lattice observed at the iPS cell stage.
2026-04-08
A new single-cell method called CIPHER-seq is giving scientists an unprecedented view of immune cell behavior, connecting genetic signals to...
2026-04-08
A series of in vitro and in vivo CRISPR activation screens combined with in situ Perturb-seq identify regulators of T cell-dependent cytotoxicity in melanoma.
2026-04-07
Whole-genome sequencing has provided definitive proof that the fish Parapriacanthus ransonneti lacks the luciferase gene essential for...
2026-04-06
Burr and Auckland et. al develop MitoPerturb-Seq, which combines single-cell screening with multiomics to link nuclear genes to mitochondrial DNA (mtDNA) dynamics. They unveil core regulators of mtDNA copy number and characterize cell-cycle delays and transcriptional stress in response to mtDNA depletion.
2026-04-01
Single-variant and ultrarare variant burden analyses leveraging exome sequencing data from 22 cohorts identify new risk genes for amyotrophic lateral sclerosis and show cumulative effects of several rare variants on disease risk.
2026-03-31
RNA sequencing (RNA-seq) has become a foundational method for identifying which genes are active within an organism. However, connecting these gene...
2026-03-31
A decade-long collaboration between Karolinska Institutet, Karolinska University Hospital, and SciLifeLab has successfully integrated whole genome...
2026-03-30
In a recent Nature Communications paper (https://www.nature.com/articles/s41467-026-68907-1), Rice University professor James Chappell and...
2026-03-26
Czernilofsky et al. identified factors that reprogram stromal cells into an inflammatory, dysfunctional state, leading to the structural disorganization of lymph nodes in B cell lymphoma at single-cell and spatial resolutions.
2026-03-25
