"Познание начинается с удивления" (Аристотель)
Новое в науке на 2025-04-25
Understanding the relationships between proteins and specific disease phenotypes contributes to the early detection of diseases and advances the development of personalized medicine. The acquisition of a...
2025-04-22
We present metacp an open-source software package which implements an abundance of statistical methods for the combination of both independent p-values, with methods such as Fisher’s, Stouffer’s and Edgington’s,...
2025-04-19
Lei et al. develop a 4-1BB co-stimulated anti-CD19 CAR-NK cell product, show efficacy in pre-clinical models, and test safety and feasibility in a phase 1 trial in patients with refractory/relapsed large B cell lymphoma.
2025-04-18
A gene regulatory network (GRN) is a graph-level representation that describes the regulatory relationships between transcription factors and target genes in cells. The reconstruction of GRNs can help...
2025-04-18
Genome-wide association studies have identified connections between genetic variations and diseases, but they only examine a small portion of single nucleotide polymorphisms. To enhance genetic findings,...
2025-04-16
Here, Arkinson et al. reconstitute NUB1-mediated FAT10 degradation by the human 26S proteasome and use biochemistry, cryo-EM and hydrogen–deuterium exchange to show that NUB1 acts as an ATP-independent chaperone to trap partially folded FAT10 for proteasome delivery.
2025-04-11
