"Жизнь коротка, наука -- бесконечна" (Гиппократ)
Новое в науке на 2025-11-16
Large-scale genome-wide analyses identify hundreds of genetic loci associated with hypothyroidism and thyroid hormone levels, demonstrating the potential of using polygenic risk scores to predict disease onset and progression.
2025-11-14
Live-cell fluorescence microscopy and polymer simulations in human HCT116 cells show similar cohesin density, residence times and extrusion speed across multiple genomic regions.
2025-11-14
Genome-wide association analyses leveraging Nordic biobanks with longitudinal health registries identify differences in the genetic architectures of early-onset and late-onset major depressive disorder and in their genetic correlations with related traits.
2025-11-13
REMETA is a method for meta-analyzing gene-based associations using summary statistics, integrating with REGENIE and improving computational efficiency for large studies with many phenotypes.
2025-11-12
Predicting drug-target interactions (DTIs) plays a pivotal role in accelerating drug repositioning by prioritizing candidate drugs and reducing experimental costs. Despite advancements in deep learning,...
2025-11-07
The authors use time-resolved cryo-electron microscopy to reveal the interactions of the redox-active cofactor TXNL1 with the human 26S proteasome and detect ATPase motor states that indicate burst-like mechanisms for hand-over-hand substrate translocation.
2025-11-06
Spatial transcriptomics have emerged as a powerful tool in biomedical research because of its ability to capture both the spatial contexts and abundance of the complete RNA transcript profile in organs of...
2025-11-06
Identifying potential associations among food, gut microbiota and disease is fundamental for elucidating interaction mechanisms and advancing personalized healthy dietary strategies. While computational...
2025-11-04
Understanding how the molecules in our bodyrespond to the co-occurrence of two diseases in an individual (comorbidity) could lead tomechanistic insights into novel treatments for comorbid conditions. Studies...
2025-10-31
In bottom-up proteomics using data-independent acquisition mass spectrometry (DIA-MS), quantitative measurements are obtained following multiple steps of protein fragmentation and ionization, which introduces...
2025-10-31
Majzner and colleagues show that engineering T cells with a membrane-tethered version of the signaling adaptor molecule SLP-76 alongside a chimeric antigen receptor (CAR) enhances CAR T cell activity against low-antigen-density tumors.
2025-10-23
