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"Познание начинается с удивления" (Аристотель)
Новое в науке на 2025-07-01

Efficacy of pembrolizumab and vorinostat combination in patients with recurrent and/or metastatic squamous cell carcinomas: a phase 2 basket trial

Borcoman and colleagues present the efficacy and safety results of the phase 2 PEVOsq basket trial investigating the combination of pembrolizumab with the epidrug vorinostat in patients with recurrent and/or metastatic squamous cell carcinoma.

2025-06-30

Differential expression analysis with inmoose, the integrated multi-omic open-source environment in Python

Differential gene expression analysis is a prominent technique for the analysis of biomolecular data to identify genetic features associated with phenotypes. Limma—for microarray data –, and edgeR and DESeq2—for...

2025-06-23

PRCFX-DT: a new graph-based approach for feature selection and classification of genomic sequences

In recent years, viral diseases have exhibited a significant incidence of infections and fatalities. The analysis of viral genomic sequences can be efficacious in evaluating the present and potentially...

2025-06-17

Start & Stop: a PhysiCell and PhysiBoSS 2.0 add-on for interactive simulation control

In computational biology, in silico simulators are vital for exploring and understanding the behavior of complex biological systems. Hybrid multi-level simulators, such as PhysiCell and PhysiBoSS 2.0, integrate...

2025-06-11

SCATrans: semantic cross-attention transformer for drug–drug interaction predication through multimodal biomedical data

Predicting potential drug-drug interactions (DDIs) from biomedical data plays a critical role in drug therapy, drug development, drug regulation, and public health. However, it remains challenging due to the...

2025-06-10

SEQSIM: A novel bioinformatics tool for comparisons of promoter regions—a case study of calcium binding protein spermatid associated 1 (CABS1)

Understanding transcriptional regulation requires an in-depth analysis of promoter regions, which house vital cis-regulatory elements such as core promoters, enhancers, and silencers. Despite the significance...

2025-06-09