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"Познание начинается с удивления" (Аристотель)
Новое в науке на 2025-03-13

Mechanistic basis for PYROXD1-mediated protection of the human tRNA ligase complex against oxidative inactivation

By using cryo-EM and biochemical assays, Loeff et al. reveal the mechanistic basis for the protective function of the oxidoreductase PYROXD1 that maintains the activity of the tRNA ligase complex under aerobic conditions.

2025-03-11

Family-based genome-wide association study designs for increased power and robustness

This study develops family-based genome-wide association study methods that maximize power in homogeneous samples through inclusion of singletons and in diverse samples by using all available parental genotypes.

2025-03-10

Selection for somatic escape variants in SERPINA1 in the liver of patients with alpha-1 antitrypsin deficiency

The expansion of clones with distinct SERPINA1 somatic mutants in the livers of alpha-1 antitrypsin deficiency (A1AT) patients is consistent with convergent evolution. These variants interfere with the auto-polymerization and intra-ER accumulation of the Z-A1AT protein, thus highlighting potentially targetable domains.

2025-03-10

SNPeBoT: a tool for predicting transcription factor allele specific binding

Mutations in non-coding regulatory regions of DNA may lead to disease through the disruption of transcription factor binding. However, our understanding of binding patterns of transcription factors and the...

2025-03-10

Constructing multilayer PPI networks based on homologous proteins and integrating multiple PageRank to identify essential proteins

Predicting and studying essential proteins not only helps to understand the fundamental requirements for cell survival and growth regulation mechanisms but also deepens our understanding of disease mechanisms...

2025-03-10

UTAP2: an enhanced user-friendly transcriptome and epigenome analysis pipeline

The emergence of next-generation sequencing (NGS) marked a revolution in biological research, enabling comprehensive characterization of the transcriptome and detailed analysis of the epigenome landscape...

2025-03-07

GoldPolish-target: targeted long-read genome assembly polishing

Advanced long-read sequencing technologies, such as those from Oxford Nanopore Technologies and Pacific Biosciences, are finding a wide use in de novo genome sequencing projects. However, long reads typically...

2025-03-07

An alignment-free method for phylogeny estimation using maximum likelihood

While alignment has traditionally been the primary approach for establishing homology prior to phylogenetic inference, alignment-free methods offer a simplified alternative, particularly beneficial when...

2025-03-07

Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W

Qi et al. used cryo-electron microscopy to determine the structures of tau filaments from the brains of individuals with MAPT mutants V337M and R406W, known to give rise to frontotemporal dementias. They showed that the tau filaments adopted the Alzheimer fold.

2025-03-05

TIGR Systems Offer a Compact Alternative to CRISPR for Gene Editing

A search for new genome-editing tools has led researchers from MIT’s McGovern Institute and the Broad Institute of MIT to identify a distinct class...

2025-03-03

Highlights from AGBT 2025 – Part II

Continuing from our previous article (https://www.seqanswers.com/forum/news/326451-highlights-from-agbt-2025-%E2%80%93-part-i), we’re reviewing the...

2025-02-28

Highlights from AGBT 2025 – Part I

Commemorating 25 years of innovation, the Advances in Genome Biology and Technology (AGBT) conference launched this year’s event at its original...

2025-02-24

Selecting the Right AI Model for Bioinformatics Research

A team of researchers led by Jianxin Wang at the School of Computer Science and Engineering, Central South University, conducted an extensive...

2025-02-21

Gene Editing Technique Removes Extra Chromosome 21 in Human Cells

A recent study demonstrates that CRISPR-based gene editing can selectively remove the extra copy of chromosome 21 in human cells. Published as a...

2025-02-18