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"Познание начинается с удивления" (Аристотель)
Новое в науке на 2026-05-13

Membrane insertion of mitochondrial-encoded proteins regulates ribosome decoding speed

Schöndorf and Petrychenko et al. show that mitochondrial translation speed is coupled to OXA1L-mediated inner membrane insertion, with cotranslational nascent chain folding and insertion driving structural changes and translational pausing.

2026-05-07

Structural basis for recognition of diverse localizing mRNAs by Egl–BicD

Singh et al. combine cryo-electron microscopy and functional studies to reveal how a single protein complex selects diverse mRNAs for subcellular localization using a combination of shape, positional sequence information and number of structured RNA elements.

2026-05-05

Tumor-localized CD40 agonism with MP0317, a FAP x CD40 DARPin, reprograms the tumor microenvironment in patients with advanced solid tumors: an open-label, nonrandomized, dose-escalation phase 1 study

In this paper, Steeghs and colleagues report the safety, activity, pharmacokinetic and pharmacodynamic results of a phase 1 dose-escalation trial with MP0317 (FAP x CD40 DARPin) monotherapy in patients with advanced solid tumors.

2026-05-01