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"Познание начинается с удивления" (Аристотель)
Новое в науке на 2025-02-09

Genetic Mapping of Plasmodium knowlesi Identifies Essential Genes and Drug Resistance Mechanisms

Researchers at Harvard T.H. Chan School of Public Health and their collaborators created a comprehensive map of genes needed for blood infections...

2025-02-07

Instance-level semantic segmentation of nuclei based on multimodal structure encoding

Accurate segmentation and classification of cell nuclei are crucial for histopathological image analysis. However, existing deep neural network-based methods often struggle to capture complex morphological...

2025-02-06

Direct coupling analysis and the attention mechanism

Proteins are involved in nearly all cellular functions, encompassing roles in transport, signaling, enzymatic activity, and more. Their functionalities crucially depend on their complex three-dimensional...

2025-02-06

Omilayers: a Python package for efficient data management to support multi-omic analysis

Multi-omic integration involves the management of diverse omic datasets. Conducting an effective analysis of these datasets necessitates a data management system that meets a specific set of requirements,...

2025-02-06

AMEND 2.0: module identification and multi-omic data integration with multiplex-heterogeneous graphs

Multi-omic studies provide comprehensive insight into biological systems by evaluating cellular changes between normal and pathological conditions at multiple levels of measurement. Biological networks, which...

2025-02-05

New DNA Sequencing Method Measures Metabolites with High Precision

Scientists from the University of Toronto have developed a new technique for small molecule sequencing named, “smol-seq.” This platform uses DNA...

2025-02-05

BioLake: an RNA expression analysis framework for prostate cancer biomarker powered by data lakehouse

Biomedical researchers must often deal with large amounts of raw data, and analysis of this data might provide significant insights. However, if the raw data size is large, it might be difficult to uncover...

2025-02-04

Fine-scale population structure and widespread conservation of genetic effect sizes between human groups across traits

This study introduces the concept of Ancestry Components and shows that they can offer improved population stratification correction for geographically correlated traits. By using ancestry-aware polygenic score construction in admixed individuals, the authors find that effect sizes are conserved across ancestry groups.

2025-02-03

A barley pan-transcriptome reveals layers of genotype-dependent transcriptional complexity

A long- and short-read barley pan-transcriptome assembled from 20 diverse barley genotypes offers insights into genotype- and tissue-dependent gene expression and function.

2025-02-03

AI Model Maps 3D Genome Structures in Minutes

A Faster, AI-Powered Approach to Chromatin Structure Prediction The three-dimensional organization of DNA within the nucleus plays a fundamental...

2025-02-03

Long-Read Sequencing Speeds Up Diagnosis of Rare Genetic Diseases

Despite advances in genetic testing, half of all rare genetic diseases remain undiagnosed. Many patients—often children—spend years undergoing...

2025-01-31

Decoding pan-cancer treatment outcomes using multimodal real-world data and explainable artificial intelligence

Keyl et al. present an explainable artificial intelligence model-based real-world data analysis from over 15,000 patients across 38 cancer types, identified key prognostic marker interactions, and confirmed these in an external lung cancer cohort.

2025-01-30

Cryo-EM structure of the NDH–PSI–LHCI supercomplex from Spinacia oleracea

Here, the authors report the structure of the nicotinamide adenine dinucleotide phosphate dehydrogenase–photosystem I–light-harvesting complex I supercomplex, providing insights into subunit interactions and the role of cofactors.

2025-01-24

A network of interacting ciliary tip proteins with opposing activities imparts slow and processive microtubule growth

Using in vitro reconstitution experiments with purified components, the authors show that five interacting ciliary tip proteins collectively form cork-like structures at microtubule tips and make microtubule growth very slow and processive.

2025-01-24

New Genome Analysis Tool Offers Scalable Phylogenomic Insights

A team of researchers led by engineers at the University of California San Diego has developed a novel approach for analyzing entire genomes. The...

2025-01-24