"Познание начинается с удивления" (Аристотель)
Новое в науке на 2024-03-29
Incorporating protein-altering copy number variants ascertained from UK Biobank whole-exome sequencing data into analyses of rare predicted loss-of-function variants identifies complex trait associations not detectable using standard analysis methods.
2024-03-28
Single-cell transcriptomics and expression quantitative trait locus mapping in 114 lung tissue samples, including 66 with interstitial lung disease, highlight the cell-type-specific functions of risk variants contributing to disease pathobiology.
2024-03-28
Single-cell RNA sequencing analysis of over 800,000 human adult breast cells from 55 female donors identifies 41 cell subtypes and highlights age- and parity-dependent effects. Samples from healthy women with germline mutations in BRCA1 or BRCA2 showed signs of T cell exhaustion.
2024-03-28
In a recent study published in Addictive Behaviors, a team led by Rachel Tomko, Ph.D., from the Medical University of South Carolina, alongside...
2024-03-28
In a significant stride toward improving colorectal cancer treatment, scientists at the Van Andel Institute in Grand Rapids, Michigan, have...
2024-03-28
Deep learning methods have emerged as powerful tools for analyzing histopathological images, but current methods are often specialized for specific domains and software environments, and few open-source...
2024-03-27
Cancer is one of the leading causes of deaths worldwide. Survival analysis and prediction of cancer patients is of great significance for their precision medicine. The robustness and interpretability of the...
2024-03-27
Classifying breast cancer subtypes is crucial for clinical diagnosis and treatment. However, the early symptoms of breast cancer may not be apparent. Rapid advances in high-throughput sequencing technology...
2024-03-27
The global spread of the SARS-CoV-2 pandemic, originating in Wuhan, China, has had profound consequences on both health and the economy. Traditional alignment-based phylogenetic tree methods for tracking...
2024-03-27
The RNA-Recognition motif (RRM) is a protein domain that binds single-stranded RNA (ssRNA) and is present in as much as 2% of the human genome. Despite this important role in biology, RRM-ssRNA interactions...
2024-03-26
Cryo-EM studies reveal that RYBP–PRC1 uses two distinct interfaces for binding unmodified and H2Aub1-modified nucleosomes. These binding modes enable the complex to generate H2Aub1 chromatin domains by a read–write mechanism.
2024-03-25
Messenger RNA (mRNA) technology, previously spotlighted for its pivotal role in COVID-19 vaccine development, is now spreading into other therapeutic...
2024-03-22
Single-cell ATAC + RNA linking (SCARlink) predicts gene expression by jointly modeling local tiled chromatin accessibility using regularized Poisson regression on multi-ome data. SCARlink predictions can be used to identify cell-type-specific enhancers and perform chromatin potential analysis.
2024-03-21
In a recent opinion piece published in the journal Trends in Genetics, researchers propose a novel perspective on aging, suggesting that the process...
2024-03-21
In a recent collaborative effort led by the Morgridge Institute for Research, scientists have successfully assembled the reference genomes for two...
2024-03-19