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"Жизнь коротка, наука -- бесконечна" (Гиппократ)
Новое в науке на 2025-03-27

Uncovering latent biological function associations through gene set embeddings

The complexity of biological systems has increasingly been unraveled through computational methods, with biological network analysis now focusing on the construction and exploration of well-defined...

2025-03-24

ChIPbinner: an R package for analyzing broad histone marks binned in uniform windows from ChIP-Seq or CUT&RUN/TAG data

The decreasing costs of sequencing, along with the growing understanding of epigenetic mechanisms driving diseases, have led to the increased application of chromatin immunoprecipitation (ChIP), Cleavage...

2025-03-24

Deep-ProBind: binding protein prediction with transformer-based deep learning model

Binding proteins play a crucial role in biological systems by selectively interacting with specific molecules, such as DNA, RNA, or peptides, to regulate various cellular processes. Their ability to recognize...

2025-03-22

Towards a standard benchmark for phenotype-driven variant and gene prioritisation algorithms: PhEval - Phenotypic inference Evaluation framework

Computational approaches to support rare disease diagnosis are challenging to build, requiring the integration of complex data types such as ontologies, gene-to-phenotype associations, and cross-species data...

2025-03-22

Prediction of drug’s anatomical therapeutic chemical (ATC) code by constructing biological profiles of ATC codes

The Anatomical Therapeutic Chemical (ATC) classification system, proposed and maintained by the World Health Organization, is among the most widely used drug classification schemes. Recently, it has become a...

2025-03-21

AI Tool Creates High-Resolution 3D Maps of the Mouse Brain

A new AI tool from University of Florida researchers generates detailed 3D mouse brain maps, offering a zoomable view of energy-producing molecules....

2025-03-20

Studying Microbial Gene Transfer with RNA Barcoding

Gene transfer is an important mechanism used by bacteria to exchange genetic material. This can allow these microorganisms to adapt to different...

2025-03-19

Mapping the snoRNAome in Zebrafish to Advance Disease Research

Small nucleolar RNAs (snoRNAs) are a group of non-coding RNAs that have shown important roles in cellular functions and disease associations....

2025-03-18

Molecular glues that inhibit deubiquitylase activity and inflammatory signaling

The BRCC36 isopeptidase complex (BRISC) is a deubiquitylase that stabilizes interferon receptors, driving inflammation. We discovered ‘BRISC molecular glue’ inhibitors (BLUEs) that selectively inactivate BRISC, promoting interferon receptor ubiquitylation and degradation to dampen immune responses.

2025-03-17

TIGR Systems Offer a Compact Alternative to CRISPR for Gene Editing

A search for new genome-editing tools has led researchers from MIT’s McGovern Institute and the Broad Institute of MIT to identify a distinct class...

2025-03-03

Highlights from AGBT 2025 – Part II

Continuing from our previous article (https://www.seqanswers.com/forum/news/326451-highlights-from-agbt-2025-%E2%80%93-part-i), we’re reviewing the...

2025-02-28