"Жизнь коротка, наука -- бесконечна" (Гиппократ)
Новое в науке на 2025-01-16
A study by Kibe et al. of the translational landscape of HIV-1 reveals alternative translation events, including use of upstream and internal open reading frames, an RNA fold regulating gag-pol frameshifting and ribosome collisions, providing new targets for antivirals.
2025-01-15
All chemical forms of energy and oxygen on Earth are generated via photosynthesis where light energy is converted into redox energy by two photosystems (PS I and PS II). There is an increasing number of PS I...
2025-01-14
Loss of Kmt2c or Kmt2d in mice drives the redeployment of KMT2A–menin to bivalent promoters, leading to changes in gene expression. This primes cells for transformation and elicits sensitivity to EGFR inhibitors.
2025-01-13
The increasing availability of sequenced genomes has enabled comparative analyses of various organisms. Numerous tools and online platforms have been developed for this purpose, facilitating the...
2025-01-13
MicroRNAs (miRNAs) are pivotal in the initiation and progression of complex human diseases and have been identified as targets for small molecule (SM) drugs. However, the expensive and time-intensive...
2025-01-13
Genomic surveillance is extensively used for tracking public health outbreaks and healthcare-associated pathogens. Despite advancements in bioinformatics pipelines, there are still significant challenges in...
2025-01-13
Drug-target interactions (DTIs) are pivotal in drug discovery and development, and their accurate identification can significantly expedite the process. Numerous DTI prediction methods have emerged, yet many...
2025-01-13
A study published in Genetics in Medicine highlights the potential of genomics-informed care in addressing the complex needs of patients with...
2025-01-10
Swanton and colleagues present a clonal expression signature, ORACLE, which, in combination with clinicopathological and molecular risk factors, can predict survival of patients with lung adenocarcinoma, and they prospectively validate its prognostic value.
2025-01-09
Sears and colleagues found that ongoing replication stress pathways and T cell clonal responses differentiate liver and lung recurrence and are associated with different clinical outcomes in the context of pancreatic ductal adenocarcinoma.
2025-01-09
Efforts to address the opioid crisis have increasingly turned to genetic testing, with the goal of identifying individuals most at risk for opioid...
2025-01-09
Analyzing single-cell gene expression data has greatly improved biological research, offering insights at a granular level that were previously...
2025-01-08
Trumpp and colleagues develop a method to obtain long-term circulating tumor cell-derived organoids from individuals with metastatic breast cancer and identify the neuregulin 1–HER3 axis as important for organoid growth and a promising therapeutic target.
2025-01-03
A new nanopore-based diagnostic tool developed by scientists at the University of California, Riverside, could revolutionize the speed and precision...
2025-01-03
Neurodegenerative diseases like Alzheimer’s (AD), Parkinson’s (PD), and dementia with Lewy bodies (DLB) affect millions worldwide, yet effective...
2024-12-30
