"Познание начинается с удивления" (Аристотель)
Новое в науке на 2025-07-14
Nardone et al. identify a metazoan protein complex (mRAVE) that assembles V-ATPases from two subcomplexes, enabling lysosome acidification, neurotransmitter vesicle loading and a lysosome damage response pathway.
2025-07-11
By probing the essentiality of diverse genes encoding mRNA translation factors in different human cell types using CRISPR interference screens, Rodschinka et al. discover that human stem cells critically depend on proteins rescuing stalled or collided ribosomes.
2025-07-11
RNA-binding proteins (RBPs) play crucial roles in gene regulation. Their dysregulation has been increasingly linked to neurodegenerative diseases, liver cancer, and lung cancer. Although experimental methods...
2025-07-11
Targeted amplicon sequencing (TAS) is a high-throughput genotyping method in which markers can be designed at desired positions. However, genotyping by TAS requires a genome-wide primer design and complex...
2025-07-11
Untargeted tandem mass spectrometry serves as a scalable solution for the organization of small molecules. One of the most prevalent techniques for analyzing the acquired tandem mass spectrometry data (MS/MS)...
2025-07-11
With the accumulation of phylogenomic data and the growing demand for bioinformatics analyses, it has become increasingly important and complex to construct evolutionary relationships for different research...
2025-07-10
Predicting protein structural similarity and detecting homologous sequences remain fundamental and challenging tasks in computational biology. Accurate identification of structural homologs enables function...
2025-07-10
Classes of autism are uncovered with a generative mixture modeling approach leveraging matched phenotypic and genetic data from a large cohort, revealing different genetic programs underlying their phenotypic and clinical traits.
2025-07-09
Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype can be rescued by mutations in the retrotransposon coding sequence.
2025-07-09
This study employs a functional genomic approach to identify a synthetic lethal interaction between CDS1 and CDS2 in uveal melanoma and other cancers, which may represent a potential therapeutic target.
2025-07-04
