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"Познание начинается с удивления" (Аристотель)
Новое в науке на 2025-07-14

A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients

Nardone et al. identify a metazoan protein complex (mRAVE) that assembles V-ATPases from two subcomplexes, enabling lysosome acidification, neurotransmitter vesicle loading and a lysosome damage response pathway.

2025-07-11

Comparative CRISPRi screens reveal a human stem cell dependence on mRNA translation-coupled quality control

By probing the essentiality of diverse genes encoding mRNA translation factors in different human cell types using CRISPR interference screens, Rodschinka et al. discover that human stem cells critically depend on proteins rescuing stalled or collided ribosomes.

2025-07-11

RMDNet: RNA-aware dung beetle optimization-based multi-branch integration network for RNA–protein binding sites prediction

RNA-binding proteins (RBPs) play crucial roles in gene regulation. Their dysregulation has been increasingly linked to neurodegenerative diseases, liver cancer, and lung cancer. Although experimental methods...

2025-07-11

MKDESIGNER and TASEQ: a set of tools for plant genotyping by targeted amplicon sequencing

Targeted amplicon sequencing (TAS) is a high-throughput genotyping method in which markers can be designed at desired positions. However, genotyping by TAS requires a genome-wide primer design and complex...

2025-07-11

An evaluation methodology for machine learning-based tandem mass spectra similarity prediction

Untargeted tandem mass spectrometry serves as a scalable solution for the organization of small molecules. One of the most prevalent techniques for analyzing the acquired tandem mass spectrometry data (MS/MS)...

2025-07-11

PhyloScape: interactive and scalable visualization platform for phylogenetic trees

With the accumulation of phylogenomic data and the growing demand for bioinformatics analyses, it has become increasingly important and complex to construct evolutionary relationships for different research...

2025-07-10

Rprot-Vec: a deep learning approach for fast protein structure similarity calculation

Predicting protein structural similarity and detecting homologous sequences remain fundamental and challenging tasks in computational biology. Accurate identification of structural homologs enables function...

2025-07-10

Decomposition of phenotypic heterogeneity in autism reveals underlying genetic programs

Classes of autism are uncovered with a generative mixture modeling approach leveraging matched phenotypic and genetic data from a large cohort, revealing different genetic programs underlying their phenotypic and clinical traits.

2025-07-09

Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes

Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype can be rescued by mutations in the retrotransposon coding sequence.

2025-07-09

The synthetic lethal interaction between CDS1 and CDS2 is a vulnerability in uveal melanoma and across multiple tumor types

This study employs a functional genomic approach to identify a synthetic lethal interaction between CDS1 and CDS2 in uveal melanoma and other cancers, which may represent a potential therapeutic target.

2025-07-04