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"Жизнь коротка, наука -- бесконечна" (Гиппократ)
Новое в науке на 2024-11-07

MIPPIS: protein–protein interaction site prediction network with multi-information fusion

The prediction of protein–protein interaction sites plays a crucial role in biochemical processes. Investigating the interaction between viruses and receptor proteins through biological techniques aids in...

2024-11-04

PangeBlocks: customized construction of pangenome graphs via maximal blocks

The construction of a pangenome graph is a fundamental task in pangenomics. A natural theoretical question is how to formalize the computational problem of building an optimal pangenome graph, making explicit...

2024-11-04

GPCR-BSD: a database of binding sites of human G-protein coupled receptors under diverse states

G-protein coupled receptors (GPCRs), the largest family of membrane proteins in human body, involve a great variety of biological processes and thus have become highly valuable drug targets. By binding with...

2024-11-04

CUDASW++4.0: ultra-fast GPU-based Smith–Waterman protein sequence database search

The maximal sensitivity for local pairwise alignment makes the Smith-Waterman algorithm a popular choice for protein sequence database search. However, its quadratic time complexity makes it...

2024-11-02

Improving crop production using an agro-deep learning framework in precision agriculture

The study focuses on enhancing the effectiveness of precision agriculture through the application of deep learning technologies. Precision agriculture, which aims to optimize farming practices by monitoring...

2024-11-01

Seq-Scope Expands Possibilities for High-Resolution Gene Expression Analysis

University of Michigan researchers have refined a unique approach for visualizing gene expression at unprecedented resolution, marking a major...

2024-11-01

Global loss of promoter–enhancer connectivity and rebalancing of gene expression during early colorectal cancer carcinogenesis

Snyder and colleagues show global loss of promoter–enhancer connectivity during early colorectal carcinogenesis and the dependency of gene dysregulation during this process on the baseline of promoter–enhancer interaction in normal colonic epithelium.

2024-10-30

Multiomic analysis of familial adenomatous polyposis reveals molecular pathways associated with early tumorigenesis

Snyder and colleagues present a comprehensive multiomic atlas of normal mucosal, benign polyps and dysplastic polyps from six persons with familial adenomatous polyposis, comprising transcriptomic, proteomic, metabolomic and lipidomic datasets.

2024-10-30

Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages

Ding and colleagues use bulk, single-cell and single-nucleus multi-omics together with spatial transcriptomics and multiplex imaging of clinical tumor samples to characterize gene expression and chromatin accessibility of breast cancer lineages.

2024-10-30

New Model Aims to Explain Polygenic Diseases by Connecting Genomic Mutations and Regulatory Networks

Scientists have long relied on statistical models to predict disease risks and uncover genetic associations, yet many of these tools function as...

2024-10-30

Small Blood Stem Cell Subset Linked to Immune System Aging

A recent study published in Cellular & Molecular Immunology suggests that a small subset of blood stem cells plays a key role in determining the...

2024-10-24

New AI Model Designs Synthetic DNA Switches for Targeted Gene Expression in Specific Cell Types

A collaboration between scientists at The Jackson Laboratory (JAX), the Broad Institute of MIT and Harvard, and Yale University has led to the...

2024-10-23

Microbes in Urban Spaces Adapt to Disinfectants and Scarce Resources

Urban environments, defined by their dense infrastructure and human activity, may be influencing the evolution of microorganisms that inhabit them. A...

2024-10-17