"Жизнь коротка, наука -- бесконечна" (Гиппократ)
Новое в науке на 2025-05-14
Genome-wide analyses identify 30 independent loci associated with obsessive–compulsive disorder, highlighting genetic overlap with other psychiatric disorders and implicating putative effector genes and cell types contributing to its etiology.
2025-05-13
Karpinska, Zhu and colleagues characterize the structure-function relationship of the genome during cellular differentiation and demonstrate a role for enhancer-promoter interactions in gene regulation that is independent of cooperative interactions in chromatin hubs.
2025-05-13
The human endoderm-derived organoid cell atlas (HEOCA) presents an integrative analysis of single-cell transcriptomes across different conditions, sources and protocols. It compares cell types and states between models, and harmonizes cell annotations through mapping to primary tissues.
2025-05-12
This study characterizes the three-dimensional (3D) genome architecture of 15 primary human cancer types from The Cancer Genome Atlas. The analyses identify different archetypes of enhancer usage and enhancer rewiring events due to different classes of mutations and structural variants.
2025-05-12
The classification of DNA sequences is pivotal in bioinformatics, essentially for genetic information analysis. Traditional alignment-based tools tend to have slow speed and low recall. Machine learning...
2025-05-09
Protein-protein interaction networks (PPINs) provide a comprehensive view of the intricate biochemical processes that take place in living organisms. In recent years, the size and information content of PPINs...
2025-05-08
The integration of deep learning, particularly AI-Generated Content, with high-quality data derived from ab initio calculations has emerged as a promising avenue for transforming the landscape of scientific...
2025-05-07
Large-scale family pedigrees are commonly used across medical, evolutionary, and forensic genetics. These pedigrees are tools for identifying genetic disorders, tracking evolutionary patterns, and...
2025-05-07
Genome sequence databases are growing exponentially, but with high redundancy and uneven data quality. For these reasons, selecting representative subsets of genomes is an essential step for almost all...
2025-05-06
Kazi et al. report the crystal structure of the mitochondrial deubiquitinase USP30, a clinical stage Parkinson’s disease drug target, in complex with a specific inhibitor. The authors delineate a framework for specific deubiquitinase inhibition.
2025-05-05
