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"Познание начинается с удивления" (Аристотель)
Новое в науке на 2025-06-18

Binding of heterochromatin protein Rhino to a subset of piRNA clusters depends on a combination of two histone marks

The authors reveal that, in fruit fly ovaries, the protein Rhino is guided to specific regions of the genome by a combination of two histone modifications, enhancing understanding of how cells protect their DNA from harmful virus-like elements.

2025-06-17

Start & Stop: a PhysiCell and PhysiBoSS 2.0 add-on for interactive simulation control

In computational biology, in silico simulators are vital for exploring and understanding the behavior of complex biological systems. Hybrid multi-level simulators, such as PhysiCell and PhysiBoSS 2.0, integrate...

2025-06-11

SCATrans: semantic cross-attention transformer for drug–drug interaction predication through multimodal biomedical data

Predicting potential drug-drug interactions (DDIs) from biomedical data plays a critical role in drug therapy, drug development, drug regulation, and public health. However, it remains challenging due to the...

2025-06-10

SEQSIM: A novel bioinformatics tool for comparisons of promoter regions—a case study of calcium binding protein spermatid associated 1 (CABS1)

Understanding transcriptional regulation requires an in-depth analysis of promoter regions, which house vital cis-regulatory elements such as core promoters, enhancers, and silencers. Despite the significance...

2025-06-09

Bigpicc: a graph-based approach to identifying carcinogenic gene combinations from mutation data

Genome data from cancer patients represents relationships between the presence of a gene mutation and cancer occurrence in a patient. Different types of cancer in human are thought to be caused by...

2025-06-07

Development and validation of an autonomous artificial intelligence agent for clinical decision-making in oncology

Ferber et al. present an autonomous artificial intelligence agent system for deployment of specialized medical oncology computational tools, validating their system across various clinical scenarios representative of typical patient care workflows.

2025-06-06

‘gitana’ (phyloGenetic Imaging Tool for Adjusting Nodes and other Arrangements), a tool for plotting phylogenetic trees into ready-to-publish figures

Phylogenetic trees are essential diagrams used in different sciences, such as evolutionary biology or taxonomy, and they depict the relationships between a given set of taxa sharing a common ancestor. So far,...

2025-06-05