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"Жизнь коротка, наука -- бесконечна" (Гиппократ)
Новое в науке на 2025-07-19

Structural basis of ClC-3 transporter inhibition by TMEM9 and PtdIns(3,5)P2

Schrecker, Son and colleagues identify the accessory subunits transmembrane protein 9 (TMEM9) and TMEM9B for chloride transporters ClC-3, ClC-4 and ClC-5 and establish the roles of TMEM9 and phosphatidylinositol 3,5-bisphosphate in the regulation of ClC-3 activity and endosomal ion homeostasis.

2025-07-16

A novel machine learning architecture to improve classification of intermediate cases in health: workflow and case study for public health

The practice of medicine has evolved significantly during the past decade, with the emergence of Machine Learning (ML) that offers the opportunity of personalized patient-tailored care. However, ML models...

2025-07-16

Cross-attention graph neural networks for inferring gene regulatory networks with skewed degree distribution

Inferring Gene Regulatory Networks (GRNs) from gene expression data is a pivotal challenge in systems biology. Most existing methods fail to consider the skewed degree distribution of genes, complicating the...

2025-07-16

LM-Merger: a workflow for merging logical models with an application to gene regulatory network models

Gene regulatory network (GRN) models provide mechanistic understanding of genetic interactions that regulate gene expression and, consequently, influence cellular behavior. Dysregulated gene expression plays...

2025-07-15

SaeGraphDTI: drug–target interaction prediction based on sequence attribute extraction and graph neural network

Accurately identifying drug–target interactions (DTI) can greatly shorten the drug development cycle and reduce the cost of drug development. In current deep learning-based DTI prediction models, the...

2025-07-15

Conformational plasticity of a BiP–GRP94 chaperone complex

BiP–glucose-regulated protein 94 chaperones are critical to the proper folding of secretory and transmembrane proteins. Brenner et al. provide biochemical and structural insight into a conserved mechanism of chaperone cooperation underlying this quality control process.

2025-07-14

MKDESIGNER and TASEQ: a set of tools for plant genotyping by targeted amplicon sequencing

Targeted amplicon sequencing (TAS) is a high-throughput genotyping method in which markers can be designed at desired positions. However, genotyping by TAS requires a genome-wide primer design and complex...

2025-07-11