"Жизнь коротка, наука -- бесконечна" (Гиппократ)
Новое в науке на 2025-11-08
The authors use time-resolved cryo-electron microscopy to reveal the interactions of the redox-active cofactor TXNL1 with the human 26S proteasome and detect ATPase motor states that indicate burst-like mechanisms for hand-over-hand substrate translocation.
2025-11-06
Spatial transcriptomics have emerged as a powerful tool in biomedical research because of its ability to capture both the spatial contexts and abundance of the complete RNA transcript profile in organs of...
2025-11-06
Genome-wide CRISPRi screens for modulators of androgen receptor (AR) protein levels using live-cell quantitative endogenous AR fluorescence reporters identify PTGES3 as a new regulator of AR stability and function in prostate cancer.
2025-11-05
This study nominates immune escape as an early event in colorectal cancer and shows how this can be driven through both genetic and epigenetic changes.
2025-11-05
Li et al. further develop a high-throughput peptide-centric local stability assay that speeds up sample preparation 100-fold and extends protein–ligand identification to membrane proteins, tissues and bacteria.
2025-11-05
Malagobadan et al. show that a DICER1 hotspot mutation, previously thought to cause partial loss of function, also leads to unexpected gain of function by activating normally silent 3p passenger microRNAs, revealing a strand-switch mechanism in tumorigenesis.
2025-11-04
Identifying potential associations among food, gut microbiota and disease is fundamental for elucidating interaction mechanisms and advancing personalized healthy dietary strategies. While computational...
2025-11-04
Understanding how the molecules in our bodyrespond to the co-occurrence of two diseases in an individual (comorbidity) could lead tomechanistic insights into novel treatments for comorbid conditions. Studies...
2025-10-31
Multimodal learning for classification tasks has recently gained significant attention in bioinformatics. Current approaches primarily concentrate on devising efficient deep learning architectures to capture...
2025-10-31
In bottom-up proteomics using data-independent acquisition mass spectrometry (DIA-MS), quantitative measurements are obtained following multiple steps of protein fragmentation and ionization, which introduces...
2025-10-31
Majzner and colleagues show that engineering T cells with a membrane-tethered version of the signaling adaptor molecule SLP-76 alongside a chimeric antigen receptor (CAR) enhances CAR T cell activity against low-antigen-density tumors.
2025-10-23
