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"Познание начинается с удивления" (Аристотель)
Новое в науке на 2026-07-31

Protein thiol alterations drive pathologic liquid–liquid phase separation in the aging brain

Vignane et al. show that age-related protein oxidation disrupts normal brain protein organization, promoting harmful condensates and aggregation linked to neurodegeneration, whereas hydrogen sulfide-driven persulfidation counteracts these effects.

2026-07-30

Multi-ancestry genome-wide association analyses provide insights into the genetic basis of Hashimoto’s thyroiditis

Multi-ancestry genome-wide association analyses of Hashimoto’s thyroiditis identify new risk loci and highlight shared genetic architecture with other autoimmune diseases and pleiotropic effects on clinical outcomes.

2026-07-29

Paired mutation calling and spatial transcriptomics identify cellular neighborhoods associated with the neoplastic outcome of mouse colitis

This study uses a mouse model of inflammatory bowel disease to explore how mutations and cellular context combine to drive the transition to malignancy.

2026-07-28

Structural and functional basis of antinociceptive action of χ-conotoxin AoIA at the noradrenaline transporter

Belleza, Zhang and colleagues showed that the χ-conotoxin χ-AoIA, a venom-derived peptide, reduces pain in mice by blocking the norepinephrine transporter more effectively than other similar peptides.

2026-07-21

Conformational plasticity of human acid-sensing ion channel 1a

Using cryo-electron microscopy, Cahill, Hartfield et al. identified six structural states of human acid-sensing ion channel 1a, revealing how acidic conditions and peptide toxins regulate channel activation and desensitization through conformational flexibility.

2026-07-16