"Познание начинается с удивления" (Аристотель)
Новое в науке на 2025-07-02
Mutational signature analysis of blood cells isolated from 23 chemotherapy-exposed samples and 9 nonexposed controls characterizes the effects of various drugs on mutational burden, signature exposure and cell types.
2025-07-01
Analysis of whole-genome sequencing data from hematopoietic stem and progenitor cells taken from patients with myeloma shows how treatment shapes clonal architecture and sheds light on the evolution of treatment-related myeloid neoplasms.
2025-07-01
Licensing of eukaryotic origins of replication with MCM double hexamers (DHs) can occur through distinct pathways. Here, Lim et al. show that in yeast, cell cycle-dependent regulation of DH formation by CDK and origin structure have co-evolved.
2025-06-30
Borcoman and colleagues present the efficacy and safety results of the phase 2 PEVOsq basket trial investigating the combination of pembrolizumab with the epidrug vorinostat in patients with recurrent and/or metastatic squamous cell carcinoma.
2025-06-30
Differential gene expression analysis is a prominent technique for the analysis of biomolecular data to identify genetic features associated with phenotypes. Limma—for microarray data –, and edgeR and DESeq2—for...
2025-06-23
In recent years, viral diseases have exhibited a significant incidence of infections and fatalities. The analysis of viral genomic sequences can be efficacious in evaluating the present and potentially...
2025-06-17
In computational biology, in silico simulators are vital for exploring and understanding the behavior of complex biological systems. Hybrid multi-level simulators, such as PhysiCell and PhysiBoSS 2.0, integrate...
2025-06-11
Predicting potential drug-drug interactions (DDIs) from biomedical data plays a critical role in drug therapy, drug development, drug regulation, and public health. However, it remains challenging due to the...
2025-06-10
Understanding transcriptional regulation requires an in-depth analysis of promoter regions, which house vital cis-regulatory elements such as core promoters, enhancers, and silencers. Despite the significance...
2025-06-09
