"Познание начинается с удивления" (Аристотель)
Новое в науке на 2024-11-21
The rewiring of molecular interactions in various conditions leads to distinct phenotypic outcomes. Differential network analysis (DINA) is dedicated to exploring these rewirings within gene and protein...
2024-11-18
Graphical representations are useful to model complex data in general and biological interactions in particular. Our main motivation is the comparison of metabolic networks in the wider context of developing...
2024-11-16
Rare copy number variants (CNVs) significantly influence the human genome and may contribute to disease susceptibility. High-throughput SNP genotyping platforms provide data that can be used for CNV...
2024-11-15
Networks have emerged as a natural data structure to represent relations among entities. Proteins interact to carry out cellular functions and protein-Protein interaction network analysis has been employed...
2024-11-14
Recently, there has been a growing interest in combining causal inference with machine learning algorithms. Double machine learning model (DML), as an implementation of this combination, has received...
2024-11-14
Pascoa et al. reveal structures of the human ceramide synthase 6 and elucidate the enzyme’s mechanism. Furthermore, the work uncovers the basis of inhibition by the mycotoxin fumonisin B1.
2024-11-11
Using AFM and cryo-EM, the authors investigate how ESCRT-III-like protein Vipp1 transitions between polymorphic forms of planar sheets and helical filaments, providing insights into membrane-repair processes.
2024-11-11
Tripathi et al. identify a noncanonical RAS•GTP activity that increases XPO1-dependent export of nuclear proteins into the cytoplasm. This depends on a RAS–RanGAP1 complex, and this export function contributes to RAS oncogenic activity.
2024-11-11
The research presented at ASHG 2024 was not the only thing exciting about the show. Several companies took this time to release new products,...
2024-11-08
This year's American Society for Human Genetics (ASHG) conference is taking place in Denver, bringing together researchers, clinicians, and industry...
2024-11-08
The authors reconstituted coat protein complex II vesicles from native membranes and used cryo-electron tomography and subtomogram averaging to reveal the arrangement of inner and outer coat layers on cargo-containing coated vesicles.
2024-11-07
University of Michigan researchers have refined a unique approach for visualizing gene expression at unprecedented resolution, marking a major...
2024-11-01
Snyder and colleagues show global loss of promoter–enhancer connectivity during early colorectal carcinogenesis and the dependency of gene dysregulation during this process on the baseline of promoter–enhancer interaction in normal colonic epithelium.
2024-10-30
Scientists have long relied on statistical models to predict disease risks and uncover genetic associations, yet many of these tools function as...
2024-10-30
A recent study published in Cellular & Molecular Immunology suggests that a small subset of blood stem cells plays a key role in determining the...
2024-10-24
