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"Жизнь коротка, наука -- бесконечна" (Гиппократ)
Новое в науке на 2026-07-10

New Analysis Splits Leukemia Into 16 Epigenomic Subgroups

Acute myeloid leukemia (AML) is one of the most aggressive of all blood cancers, and how it is classified helps determine how each patient is...

2026-07-09

Identifying critical lysines in mammalian histone H3 with high-throughput CRISPR prime editing

This study uses a precise and efficient clustered regularly interspaced short palindromic repeats (CRISPR) prime editing system to substitute lysine residues in histone H3, individually or in combination, identifying those essential for mouse embryonic stem cell self-renewal.

2026-07-08

A blended genome and exome sequencing method captures genetic variation in an unbiased and cost-effective manner

Blended genome exome (BGE) is a sequencing method that captures genetic variation in an unbiased and cost-effective manner. Applying BGE to sequence samples from underrepresented populations leads to improved variant discovery.

2026-07-08

Genome-Wide CRISPR Screen Uncovers Unlikely Psoriasis Target

Biohub researchers performed what they believe is the first genome-wide CRISPR study of primary human adult skin cells, then used an AI model to mine...

2026-07-08

Engineered Protein Motor Takes Its First Steps Along DNA Track

An international team led by Lund University and the University of New South Wales has built an artificial protein motor that takes controlled,...

2026-07-07

Promoter reinforcement supports transcriptional resilience in drug-resistant cancer

Kameswaran et al. show that cancer cells can restore gene expression after TEAD inhibition by shifting control from enhancers to promoters, a process termed ‘promoter reinforcement’, enabling transcription despite disrupted promoter–enhancer communication.

2026-07-06

Spatial transcriptomic analyses highlight distinct erythroid niches in mice and humans

Spatial transcriptomic profiling of erythroblastic islands across tissues and developmental stages highlights distinct spatial architecture in humans compared to mice.

2026-07-02

High-Resolution Sequencing Exposes Hidden Toxoplasma Diversity

An international research team has used high-resolution sequencing to reveal previously hidden genetic diversity in Toxoplasma gondii. The study,...

2026-07-02

IDH1-mutant vaccine in newly diagnosed astrocytoma: final analysis of the multicenter, single-arm, open-label, first-in-human phase 1 NOA16 trial

In the multicenter, single-arm, open-label, first-in-human phase 1 NOA16 trial, Platten and colleagues report the long-term clinical and immunological follow-up outcomes of a vaccine targeting mutant IDH1 in persons with astrocytoma.

2026-07-01

New AI Model Captures Long-Range Genomic Signals to Improve RNA Splice Site Prediction

A deep learning model developed at the University of Tokyo can analyze DNA sequences spanning up to 100,000 base pairs to predict RNA splice sites...

2026-06-30