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"Познание начинается с удивления" (Аристотель)
Новое в науке на 2025-12-05

Translational activators align mRNAs at the small mitoribosomal subunit for translation initiation

Mitochondrial translational activators (TAs) facilitate transcript-specific translation. Using selective ribosome profiling and cryo-electron microscopy, the authors show that TAs bind to the 5′ untranslated region of their target transcript to position mitoribosomes for initiation.

2025-12-03

Ribozyme Assembly Captured in Motion

A new study in Nature Communications presents a detailed look at how a self-splicing ribozyme builds its functional structure. The work, led by Marco...

2025-12-01

A genome-wide association study of mass spectrometry proteomics using a nanoparticle enrichment platform

Genome-wide association analyses of blood plasma samples using a mass spectrometry-based platform illustrate the complementarity of different proteomics approaches for identifying protein quantitative trait loci.

2025-11-27

New Study Identifies Mutation Hotspot at Gene Start Sites

A large population analysis has identified a mutational hotspot at human transcription start sites. The work, published in Nature Communications,...

2025-11-26

Heterochromatin boundaries maintain centromere position, size and number

Carty et al. identify the H3K9 methyltransferases that restrict the size and position of the centromere protein A chromatin domain, maintaining functional centromeres.

2025-11-25

Brain Enzyme OTULIN Regulates Tau Production in Alzheimer’s Models

A new study in Genomic Psychiatry reports that the deubiquitinase OTULIN shapes tau production by altering gene expression and RNA metabolism,...

2025-11-25

New Modeling Tool Predicts How Microbes Respond to Diet and Disease

A research team at the University of California San Diego (UCSD) has introduced coralME, a computational tool designed to build genome-scale models...

2025-11-21

SMMILe enables accurate spatial quantification in digital pathology using multiple-instance learning

Gao et al. present SMMILe, a multiple-instance learning-based tool that leverages whole-slide images for accurate spatial quantification without compromising on classification performance, and show it outperforms state-of-the-art methods.

2025-11-19

Genetic Patterns Linked to Early Depression and Suicide Risk

A large Nordic study reports that depression emerging in young adulthood carries a stronger hereditary signal than depression that starts later in...

2025-11-13