"Жизнь коротка, наука -- бесконечна" (Гиппократ)
Новое в науке на 2025-12-09
Saturation mutagenesis screening examines 11,520 point mutations in the kinase domains of FGFR1, FGFR2, FGFR3 and FGFR4, identifying their activating and resistance properties to the FGFR inhibitors pemigatinib and futibatinib.
2025-12-08
Riechmann et al. uncover structural features governing ubiquitin transfer from ubiquitin-activating E1 enzymes UBA1 and UBA6 to specific E2 ubiquitin-conjugating enzymes, revealing a hierarchy of E2 activity with cognate E1s.
2025-12-05
Mitochondrial translational activators (TAs) facilitate transcript-specific translation. Using selective ribosome profiling and cryo-electron microscopy, the authors show that TAs bind to the 5′ untranslated region of their target transcript to position mitoribosomes for initiation.
2025-12-03
A new study in Nature Communications presents a detailed look at how a self-splicing ribozyme builds its functional structure. The work, led by Marco...
2025-12-01
Genome-wide association analyses of blood plasma samples using a mass spectrometry-based platform illustrate the complementarity of different proteomics approaches for identifying protein quantitative trait loci.
2025-11-27
A large population analysis has identified a mutational hotspot at human transcription start sites. The work, published in Nature Communications,...
2025-11-26
A new study in Genomic Psychiatry reports that the deubiquitinase OTULIN shapes tau production by altering gene expression and RNA metabolism,...
2025-11-25
A research team at the University of California San Diego (UCSD) has introduced coralME, a computational tool designed to build genome-scale models...
2025-11-21
Gao et al. present SMMILe, a multiple-instance learning-based tool that leverages whole-slide images for accurate spatial quantification without compromising on classification performance, and show it outperforms state-of-the-art methods.
2025-11-19
A large Nordic study reports that depression emerging in young adulthood carries a stronger hereditary signal than depression that starts later in...
2025-11-13
