"Познание начинается с удивления" (Аристотель)
Новое в науке на 2026-06-24
The authors use single-cell multi-omics to interrogate longitudinal samples of isocitrate dehydrogenase mutant gliomas. Their analyses couple progression and hypomethylation with changes in differentiation topologies and increased emergence of stem-like states in aggressive disease.
2026-06-22
INGENE and MODULE enhance gene expression prediction by capturing the effects of trans-eQTLs acting within coexpression networks. Integrating cis and trans predictions improves expression imputation for transcriptome-wide association studies.
2026-06-22
Whole-genome sequencing of 40 individuals from the Faroe Islands has shed new light on how this remote North Atlantic population descended from an...
2026-06-17
Atomistic structural ensembles of protein folding intermediates on the ribosome are resolved by comprehensive 19F nuclear magnetic resonance analyses integrated with molecular dynamics simulations, providing insights into cotranslational folding pathways.
2026-06-16
IBDverse is a single-cell RNA atlas of terminal ileal biopsies comprising 1.1 million cells from 111 patients with Crohn’s disease and 232 healthy participants. Analysis of the data identifies genes, pathways and cell populations associated with the disease and implicates inflammatory monocytes and macrophages in disease susceptibility.
2026-06-15
Veit et al. present a fluorescence microscopy platform to measure protein scramblase-mediated lipid flipflop across membranes by imaging single vesicles containing fluorescent lipid probes to quantify precise transport rates.
2026-06-15
Chu et al. conducted multiomic analyses of samples from 173 treatment-naive individuals with acute myeloid leukemia, integrating proteogenomic and metabolomic modalities to identify subtypes, and developed a machine-learning approach to find therapy targets.
2026-06-12
Neville et al. show that DRT1 synthesizes semirandom DNA adducts to stabilize a filamentous state. C-terminal pseudoknots form along the axis of the filament. The pseudoknot conformation inhibits a nitrilase domain, preventing abortive infection.
2026-06-10
Sloths are the slowest mammals on Earth, and their dense jungle habitat has made them notoriously difficult to study. Now, for the first time,...
2026-06-09
Hantavirus infections are rare—roughly 30 people are infected in the United States each year—but they are deadly, killing 30 to 40 percent of those...
2026-06-05
Scientists at Weill Cornell Medicine and the New York Genome Center have developed a new method that maps, in single cells, the DNA binding sites of...
2026-06-04
Scientists at University Medical Center Utrecht have identified a previously underappreciated mechanism that helps immune cells respond rapidly to...
2026-06-02
