Site logo

"Познание начинается с удивления" (Аристотель)
Новое в науке на 2025-09-16

Arp2/3-mediated bidirectional actin assembly by SPIN90 dimers

Liu et al. show that SPIN90 dimerizes and binds two Arp2/3 complexes to nucleate two bidirectional actin filaments and the dimerization domain is conserved in multicellular animals, suggesting that the mechanism of bidirectional actin filament nucleation is conserved.

2025-09-15

Towards the genome-scale discovery of bivariate monotonic classifiers

Bivariate monotonic classifiers (BMCs) are based on pairs of input features. Like many other models used for machine learning, they can capture nonlinear patterns in high-dimensional data. At the same time,...

2025-09-02

SANS ambages: phylogenomics with abundance-filter, multi-threading, and bootstrapping on amino-acid or genomic sequences

The increasing amount of available genome sequence data enables large-scale comparative studies. A common task is the inference of phylogenies– a challenging task if close reference sequences are not...

2025-09-02

Weighted overlapping group lasso for integrating prior network knowledge into gene set analysis

Gene set analysis aims to identify gene sets containing differentially expressed genes between two different experimental conditions. A representative example of gene sets is a gene regulatory network where...

2025-09-01

DeepSEA: an alignment-free explainable approach to annotate antimicrobial resistance proteins

Antimicrobial resistance (AMR) is one of the most concerning modern threats as it places a greater burden on health systems than HIV and malaria combined. Current surveillance strategies for tracking...

2025-09-01

Effective primer design for genotype and subtype detection of highly divergent viruses in large scale genome datasets

Identification of microorganisms in a biological sample is a crucial step in diagnostics, pathogen screening, biomedical research, evolutionary studies, agriculture, and biological threat assessment. While...

2025-09-01