"Познание начинается с удивления" (Аристотель)
Новое в науке на 2026-06-13
This study investigates the consequences of hypermethylation in a progeria syndrome caused by gain-of-function DNMT3A mutations, finding effects on adult stem cell function.
2026-06-12
Chu et al. conducted multiomic analyses of samples from 173 treatment-naive individuals with acute myeloid leukemia, integrating proteogenomic and metabolomic modalities to identify subtypes, and developed a machine-learning approach to find therapy targets.
2026-06-12
Neville et al. show that DRT1 synthesizes semirandom DNA adducts to stabilize a filamentous state. C-terminal pseudoknots form along the axis of the filament. The pseudoknot conformation inhibits a nitrilase domain, preventing abortive infection.
2026-06-10
Jin et al. developed an artificial intelligence tool that leverages histology to predict methylation-based central nervous system tumor subtypes and validated it for tumor classification, demonstrating high confidence and accuracy across clinical cohorts.
2026-06-10
Hu et al. show that physiological temperature and intrinsic Ca2+ reprogram TRPM4 pharmacology, revealing hidden ligand activities missed under simplified assay conditions—even at structurally stable sites—and highlighting the need for environment-aware drug discovery.
2026-06-09
Sloths are the slowest mammals on Earth, and their dense jungle habitat has made them notoriously difficult to study. Now, for the first time,...
2026-06-09
In this phase 1/2 BEGONIA platform trial, Schmid and colleagues evaluated the safety and efficacy of durvalumab and trastuzumab deruxtecan in participants with locally advanced unresectable or metastatic hormone-receptor-negative breast cancer with low human epidermal growth factor receptor 2.
2026-06-08
Hantavirus infections are rare—roughly 30 people are infected in the United States each year—but they are deadly, killing 30 to 40 percent of those...
2026-06-05
Tabatabai et al. evaluated the safety of intrathecal administration of nivolumab in participants with leptomeningeal disease in the IT-PD1/NOA-26 phase 1 clinical trial.
2026-06-04
Scientists at Weill Cornell Medicine and the New York Genome Center have developed a new method that maps, in single cells, the DNA binding sites of...
2026-06-04
Scientists at University Medical Center Utrecht have identified a previously underappreciated mechanism that helps immune cells respond rapidly to...
2026-06-02
DNA methylation is one of the most studied epigenetic modifications, yet its ancestral function in animals and its capacity for transgenerational...
2026-06-02
Here the authors show that collapse of single replication forks causes recombination, end fusions or degradation but does not restart DNA synthesis. In contrast, collapse of convergent forks completes DNA synthesis through error-prone double-strand break repair.
2026-05-27
In this study, the authors use the Caenorhabditis elegans model organism to show that maternal microRNAs are delivered from the intestine to embryos by the yolk, where they regulate gene expression and promote stress resilience in offspring.
2026-05-22
