"Жизнь коротка, наука -- бесконечна" (Гиппократ)
Новое в науке на 2025-07-19
Schrecker, Son and colleagues identify the accessory subunits transmembrane protein 9 (TMEM9) and TMEM9B for chloride transporters ClC-3, ClC-4 and ClC-5 and establish the roles of TMEM9 and phosphatidylinositol 3,5-bisphosphate in the regulation of ClC-3 activity and endosomal ion homeostasis.
2025-07-16
The practice of medicine has evolved significantly during the past decade, with the emergence of Machine Learning (ML) that offers the opportunity of personalized patient-tailored care. However, ML models...
2025-07-16
Inferring Gene Regulatory Networks (GRNs) from gene expression data is a pivotal challenge in systems biology. Most existing methods fail to consider the skewed degree distribution of genes, complicating the...
2025-07-16
Gene regulatory network (GRN) models provide mechanistic understanding of genetic interactions that regulate gene expression and, consequently, influence cellular behavior. Dysregulated gene expression plays...
2025-07-15
Accurately identifying drug–target interactions (DTI) can greatly shorten the drug development cycle and reduce the cost of drug development. In current deep learning-based DTI prediction models, the...
2025-07-15
BiP–glucose-regulated protein 94 chaperones are critical to the proper folding of secretory and transmembrane proteins. Brenner et al. provide biochemical and structural insight into a conserved mechanism of chaperone cooperation underlying this quality control process.
2025-07-14
Targeted amplicon sequencing (TAS) is a high-throughput genotyping method in which markers can be designed at desired positions. However, genotyping by TAS requires a genome-wide primer design and complex...
2025-07-11
