"Познание начинается с удивления" (Аристотель)
Новое в науке на 2026-01-12
Wu and colleagues present the efficacy and safety results from the phase 3 SCORES trial evaluating suvemcitug plus chemotherapy in persons with platinum-refractory or resistant recurrent ovarian cancer.
2026-01-09
This study uses a high-dimensional proteomics panel to explore protein-level genetic associations with type 2 diabetes in a Ugandan cohort.
2026-01-08
Cosgun et al. show that, in B cell leukemia, β-catenin expression is maintained at low levels through glycogen synthase kinase 3B (GSK3β)-mediated phosphorylation. Inhibition of GSK3β results in β-catenin–Ikaros–NuRD complex formation, leading to B-ALL cell death through MYC repression.
2026-01-08
An extensive genetic analysis involving more than 900,000 people has revealed that specific DNA segments composed of short, repetitive sequences...
2026-01-08
By performing a CAR-adapted base-editing screen of phosphatidylinositol-3-kinase delta (PI3Kδ, PIK3CD), Bucher et al. identify mutations affecting endogenous PI3K–AKT signaling that enhances CAR T cell antitumor potency.
2026-01-06
A massive nationwide effort led by Johns Hopkins University geneticists is cataloging the soil microbiome across the United States, revealing more...
2026-01-06
Ahmad et al. show that soluble histone H4 binds at histone genes and acts as a repressor of their expression. These findings suggest that histone H4 is a sensor of ongoing DNA replication. Ongoing chromatin assembly uses up soluble H4 and relieves histone gene repression; however, once DNA replication ceases, soluble H4 accumulates and represses the histone genes.
2026-01-05
An international research team has used genome-wide CRISPR knockout screening to identify hundreds of genes required for early brain development,...
2026-01-05
Cancer relapse after chemotherapy and bacterial persistence after antibiotics often trace back to a small fraction of cells that behave differently...
2026-01-03
This paper introduces breakage–replication/fusion, a genomic rearrangement process underpinning three patterns of copy-number gains found in cancer and other diseases.
2026-01-02
Nature Methods has named electron microscopy-based connectomics its Method of the Year 2025, recognizing recent advances that have made large-scale...
2025-12-30
Zeng et al. applied single-particle cryo-electron microscopy to native samples isolated from the human parasite Toxoplasma gondii, determining multiple structures of key components of the conoid, a cone-shaped organelle essential for host cell invasion.
2025-12-09
