"Познание начинается с удивления" (Аристотель)
Новое в науке на 2025-08-21
This multiomic study, including single-nucleus DNA methylation and chromatin conformation matched with single-nuclei RNA sequencing, provides insights into the epigenomic landscape of human subcutaneous adipose tissue.
2025-08-20
New concepts for comparing the genomes of 27 naturally inbred Arabidopsis thaliana accessions provide essential insights into obtaining a less biased view of whole-genome polymorphism.
2025-08-19
Human Leukocyte Antigens (HLA) play central roles in histocompatibility and immune system functions, including antigen presentation. Accurate typing of Class I and II HLA genes is crucial for transplant...
2025-08-19
In cancer research, different levels of high-dimensional data are often collected for the same subjects. Effective integration of these data by considering the shared and specific information from each data...
2025-08-19
Genetic association studies play a pivotal role in identifying disease-associated variants, but researchers face challenges in performing essential calculations like Hardy–Weinberg equilibrium testing, odds...
2025-08-19
This study uses chromatin tracing to identify alterations in single-cell 3D genome conformation during the progression of Kras-driven mouse lung adenocarcinoma and pancreatic ductal adenocarcinoma, and proposes Rnf2 as a regulator of the 3D genome.
2025-08-18
Integrated structural biology approach leveraging in situ cryo-electron tomography reveals molecular details of the native malarial translation elongation cycle and its perturbation by cabamiquine, a potent antimalarial drug candidate.
2025-08-18
Estimating the time since HIV infection (TSI) at population level is essential for tracking changes in the global HIV epidemic. Most methods for determining TSI give a binary classification of infections as...
2025-08-14
The rapid expansion of next-generation sequencing (NGS) technologies has generated vast amounts of genomic data, creating a growing demand for secure, scalable, and accessible tools to support variant...
2025-08-13
The authors reveal a three-domain architecture of glycoprotein clusterin and show that the hydrophobic tails are crucial for clusterin’s functions as an extracellular molecular chaperone and apolipoprotein, as well as for receptor binding and cellular uptake.
2025-08-08
