"Познание начинается с удивления" (Аристотель)
Новое в науке на 2024-11-13
Pascoa et al. reveal structures of the human ceramide synthase 6 and elucidate the enzyme’s mechanism. Furthermore, the work uncovers the basis of inhibition by the mycotoxin fumonisin B1.
2024-11-11
Using AFM and cryo-EM, the authors investigate how ESCRT-III-like protein Vipp1 transitions between polymorphic forms of planar sheets and helical filaments, providing insights into membrane-repair processes.
2024-11-11
Tripathi et al. identify a noncanonical RAS•GTP activity that increases XPO1-dependent export of nuclear proteins into the cytoplasm. This depends on a RAS–RanGAP1 complex, and this export function contributes to RAS oncogenic activity.
2024-11-11
Viral proteins that evade the host’s innate immune response play a crucial role in pathogenesis, significantly impacting viral infections and potential therapeutic strategies. Identifying these proteins...
2024-11-09
Stochastic models are commonly employed in the system and synthetic biology to study the effects of stochastic fluctuations emanating from reactions involving species with low copy-numbers. Many important...
2024-11-08
Proteins interact with each other in complex ways to perform significant biological functions. These interactions, known as protein–protein interactions (PPIs), can be depicted as a graph where proteins are...
2024-11-08
The research presented at ASHG 2024 was not the only thing exciting about the show. Several companies took this time to release new products,...
2024-11-08
This year's American Society for Human Genetics (ASHG) conference is taking place in Denver, bringing together researchers, clinicians, and industry...
2024-11-08
The authors reconstituted coat protein complex II vesicles from native membranes and used cryo-electron tomography and subtomogram averaging to reveal the arrangement of inner and outer coat layers on cargo-containing coated vesicles.
2024-11-07
Antibodies play a crucial role in disease treatment, leveraging their ability to selectively interact with the specific antigen. However, screening antibody gene sequences for target antigens via biological...
2024-11-06
The increasing antimicrobial resistance caused by the improper use of antibiotics poses a significant challenge to humanity. Rapid and accurate identification of microbial species in clinical settings is...
2024-11-06
University of Michigan researchers have refined a unique approach for visualizing gene expression at unprecedented resolution, marking a major...
2024-11-01
Snyder and colleagues show global loss of promoter–enhancer connectivity during early colorectal carcinogenesis and the dependency of gene dysregulation during this process on the baseline of promoter–enhancer interaction in normal colonic epithelium.
2024-10-30
Snyder and colleagues present a comprehensive multiomic atlas of normal mucosal, benign polyps and dysplastic polyps from six persons with familial adenomatous polyposis, comprising transcriptomic, proteomic, metabolomic and lipidomic datasets.
2024-10-30
Ding and colleagues use bulk, single-cell and single-nucleus multi-omics together with spatial transcriptomics and multiplex imaging of clinical tumor samples to characterize gene expression and chromatin accessibility of breast cancer lineages.
2024-10-30
Scientists have long relied on statistical models to predict disease risks and uncover genetic associations, yet many of these tools function as...
2024-10-30
A recent study published in Cellular & Molecular Immunology suggests that a small subset of blood stem cells plays a key role in determining the...
2024-10-24
