"Познание начинается с удивления" (Аристотель)
Новое в науке на 2026-05-04
In this paper, Steeghs and colleagues report the safety, activity, pharmacokinetic and pharmacodynamic results of a phase 1 dose-escalation trial with MP0317 (FAP x CD40 DARPin) monotherapy in patients with advanced solid tumors.
2026-05-01
Genome-wide association and fine-mapping analyses of type 1 diabetes (T1D) identify multiple genetic risk signals. Furthermore, a machine learning model, T1GRS, improves the prediction of T1D in individuals with complex risk profiles and identifies genetic subgroups.
2026-04-30
The authors performed computational and experimental analyses to reveal how Smoothened directly inhibits PKA through an intrinsically disordered region, defining a central step in Hedgehog signaling and a mechanism of G-protein-coupled receptor–kinase regulation.
2026-04-30
The authors show that MTCH2 promotes BAX and BAK oligomerization independently of its insertase activity, supporting its role in shaping the mitochondrial lipid environment that enables efficient pore expansion, mitochondrial DNA release and inflammatory signaling.
2026-04-29
Every human cell compacts more than six feet of DNA into a microscopic space by wrapping it around protein complexes known as nucleosomes. This...
2026-04-29
Here, the authors elucidate TMPRSS2 protease recognition of the SARS-CoV-2 spike S2′ cleavage site, revealing the molecular basis of activation of membrane fusion, and show that antibodies recognizing the S2′ site or TMPRSS2 block viral entry by interfering with TMPRSS2 access.
2026-04-28
Researchers at VIB and VUB have developed a sequencing-driven approach to study how immune cells behave within lung tumors. By combining a...
2026-04-27
An international research team has sequenced the largest genomic dataset yet assembled for Indigenous peoples of the Americas, generating 199 genomes...
2026-04-22
New research suggests that autoimmune diseases may be driven by DNA changes in immune cells that remove natural restraints on the immune system. The...
2026-04-15
Clinical use of CRISPR-based gene editing has mostly involved modifying cells outside the body before reintroducing them. A key challenge has been...
2026-04-13
