"Познание начинается с удивления" (Аристотель)
Новое в науке на 2026-09-15
Ciapponi et al. determine the cryo-electron microscopy structure of the canonical Polycomb repressive complex 1 holocomplex and show how its architecture coordinates complex assembly, H2A monoubiquitination and genomic targeting.
2026-09-14
Genomic analyses in populations of East Asian ancestry identify rare copy number variants associated with schizophrenia. Meta-analyses with populations of European ancestry identify additional risk loci enriched in genes less tolerant to loss-of-function variants.
2026-09-11
Cancer treatment alters the selection of preexisting somatic mutations in the normal esophagus, including druggable mutants that confer treatment resilience to normal cells.
2026-09-11
Lai et al. show that Nakaseomyces glabratus is enriched in fecal and tumor samples of patients with castration-resistant prostate cancer and that administration of the fungus accelerates cancer progression in prostate cancer-bearing castrated mice.
2026-09-09
Like charges normally repel one another, yet DNA molecules must pair up inside living cells to carry out essential biological processes, including...
2026-09-09
More than two decades after scientists first sequenced the human genome’s 3 billion DNA letters, most of that code’s meaning remains unclear. Only 1...
2026-09-09
Researchers at the University of East Anglia have identified shared biological mechanisms that may help explain chronic exhaustion in conditions...
2026-09-03
Scientists have long understood that each of the roughly 20,000 genes in the human body carries the instructions for a single kind of protein....
2026-09-02
Proteasomes are essential for male fertility. Kolata, dos Santos, Dendooven and colleagues show large nuclear proteasomal assemblies segregated from DNA in human sperm, forming after meiosis and with a unique α4s isoform. A native substrate is bound at the 20S catalytic site.
2026-09-01
In this open-label, single-arm, phase 1 GlutaPanc trial, Gong and colleagues report the safety and feasibility of l-glutamine in participants with advanced pancreatic ductal adenocarcinoma and determine the recommended phase 2 dose of l-glutamine in combination with gemcitabine and nab-paclitaxel.
2026-08-31
Researchers at the Land Institute and the HudsonAlpha Institute for Biotechnology have produced the first chromosome-scale, haplotype-phased genome...
2026-08-24
