Site logo

"Жизнь коротка, наука -- бесконечна" (Гиппократ)
Новое в науке на 2026-05-08

Membrane insertion of mitochondrial-encoded proteins regulates ribosome decoding speed

Schöndorf and Petrychenko et al. show that mitochondrial translation speed is coupled to OXA1L-mediated inner membrane insertion, with cotranslational nascent chain folding and insertion driving structural changes and translational pausing.

2026-05-07

Study Reveals HELQ Promotes Replication Fork Remodeling

During cell division, DNA replication faces constant threats from interstrand crosslinks (ICLs) that chemically fuse DNA strands, halting the...

2026-05-07

Structural basis for recognition of diverse localizing mRNAs by Egl–BicD

Singh et al. combine cryo-electron microscopy and functional studies to reveal how a single protein complex selects diverse mRNAs for subcellular localization using a combination of shape, positional sequence information and number of structured RNA elements.

2026-05-05

New Method Enables Non-Destructive Tracking of Gene Expression

A research team led by Gil Westmeyer at the Technical University of Munich (TUM) has developed a method that allows scientists to analyze gene...

2026-05-05

Tumor-localized CD40 agonism with MP0317, a FAP x CD40 DARPin, reprograms the tumor microenvironment in patients with advanced solid tumors: an open-label, nonrandomized, dose-escalation phase 1 study

In this paper, Steeghs and colleagues report the safety, activity, pharmacokinetic and pharmacodynamic results of a phase 1 dose-escalation trial with MP0317 (FAP x CD40 DARPin) monotherapy in patients with advanced solid tumors.

2026-05-01

Genetic association and machine learning improve the prediction of type 1 diabetes risk

Genome-wide association and fine-mapping analyses of type 1 diabetes (T1D) identify multiple genetic risk signals. Furthermore, a machine learning model, T1GRS, improves the prediction of T1D in individuals with complex risk profiles and identifies genetic subgroups.

2026-04-30

Nucleosome Structure Shapes DNA Accessibility in Cells, Study

Every human cell compacts more than six feet of DNA into a microscopic space by wrapping it around protein complexes known as nucleosomes. This...

2026-04-29

Single-Cell Sequencing Tracks Immune Cells Inside Lung Tumors

Researchers at VIB and VUB have developed a sequencing-driven approach to study how immune cells behave within lung tumors. By combining a...

2026-04-27

International Team Sequences the Genomes of Indigenous Peoples Across the Americas

An international research team has sequenced the largest genomic dataset yet assembled for Indigenous peoples of the Americas, generating 199 genomes...

2026-04-22