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"Жизнь коротка, наука -- бесконечна" (Гиппократ)
Новое в науке на 2026-04-30

MTCH2 promotes BAX and BAK self-assembly and apoptotic pore growth

The authors show that MTCH2 promotes BAX and BAK oligomerization independently of its insertase activity, supporting its role in shaping the mitochondrial lipid environment that enables efficient pore expansion, mitochondrial DNA release and inflammatory signaling.

2026-04-29

TMPRSS2-mediated coronavirus spike activation and inhibition

Here, the authors elucidate TMPRSS2 protease recognition of the SARS-CoV-2 spike S2′ cleavage site, revealing the molecular basis of activation of membrane fusion, and show that antibodies recognizing the S2′ site or TMPRSS2 block viral entry by interfering with TMPRSS2 access.

2026-04-28

Telomere-to-telomere genome assemblies and population resequencing of diploid and allotetraploid peanut varieties

Telomere-to-telomere genome assemblies for two diploid and four tetraploid peanut varieties provide insights into peanut genome organization, evolutionary dynamics and phenotypic differentiation.

2026-04-24

TMEM87A suppresses ferroptosis and increases cancer immunotherapy resistance by maintaining the Golgi apparatus pH homeostasis

Li et al. show that TMEM87a maintains the Golgi pH homeostasis in response to ferroptosis-induced Golgi lipid peroxidation. TMEM87a ablation sensitizes multiple cancer types to ferroptosis, increasing antitumor immunity and response to immunotherapy.

2026-04-21