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"Жизнь коротка, наука -- бесконечна" (Гиппократ)
Новое в науке на 2026-03-03

mcfDNA-Seq Used to Predict Bloodstream Infections in Children with Leukemia

A team at St. Jude Children’s Research Hospital has identified a potential way to predict bloodstream infections in children with high-risk leukemia...

2026-03-02

Stress adaptation of mitochondrial protein import by OMA1-mediated degradation of DNAJC15

Kroczek et al show that degradation of DNAJC15 by OMA1 and AFG3L2 under stress limits mitochondrial protein import and OXPHOS biogenesis. Non-imported proteins lead to the induction of the unfolded protein responses from the endoplasmic reticulum.

2026-02-27

Study Finds Early Pancreatic Cells Organize to Evade Immunity

A recent investigation uncovers how precancerous pancreatic cells form structured clusters and interact with immune cells to potentially suppress...

2026-02-27

Genome-wide association analyses of autoimmune hypothyroidism reveal autoimmune and thyroid-specific contributions and an inverse relationship with cancer risk

Genome-wide analyses identify 418 independent associations with autoimmune hypothyroidism and classify risk loci into distinct groupings related to systemic autoimmunity and thyroid-specific dysfunction.

2026-02-26

Transposable element–gene chimera cartography, origination and role in enhancing transcriptome plasticity

Leveraging long-read RNA sequencing and multiomics analyses, Cheon and Alvstad et al. systematically map transposable element (TE)-derived isoforms across species and cell states, revealing RNA quality control mechanisms regulating TE–gene chimeras that shape transcriptome plasticity.

2026-02-25

Three-dimensional genome reorganization foreshadows zygotic genome activation in Drosophila

Pico-C, a low-input Micro-C approach, reveals that dynamic three-dimensional genome folding precedes zygotic genome activation in Drosophila.

2026-02-24

Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs

METALoci, a new three-dimensional genome computational tool, reveals a major rewiring of regulatory interactions during sex determination. By combining this method with transgenic models, the authors identify a noncoding regulatory region at the Fgf9 locus and reveal that Meis genes are key regulators of sexual differentiation.

2026-02-24

The GENEVA platform models tumor mosaicism to reveal variations of responses to KRAS inhibitors and identify improved drug combinations

Yu et al. develop a platform to model genetic diversity in drug treatment at the single-cell level. Using KRAS-G12C inhibitors as a proof of concept, they identify the pathway driving cell death and potential resistance mechanisms.

2026-02-24

UPenn Scientists Develop Better Base Editor

Engineers from the University of Pennsylvania and Rice University have developed an improved base editor that can edit individual genetic base pairs...

2026-02-23

Study Sheds Light on Epigenetic Transgenerational Inheritance from Fungicide Exposure

In a recent study, Washington State University scientists showed that a single prenatal vinclozolin exposure increases disease risk across 20 rat...

2026-02-20

Whole Genome Sequencing Gives Insights into Ancient Resistome

A Romanian research team analyzed a bacterial strain from a 5,000-year-old ice layer in Scarisoara Ice Cave, uncovering resistance to modern...

2026-02-17