"Жизнь коротка, наука -- бесконечна" (Гиппократ)
Новое в науке на 2026-09-02
Proteasomes are essential for male fertility. Kolata, dos Santos, Dendooven and colleagues show large nuclear proteasomal assemblies segregated from DNA in human sperm, forming after meiosis and with a unique α4s isoform. A native substrate is bound at the 20S catalytic site.
2026-09-01
Kücükköse, Luzarowski and colleagues show that removing a single N-terminal amino acid during the maturation of newly imported mitochondrial proteins globally stabilizes mitochondrial protein complexes, revealing an unexpected layer of regulation of mitochondrial proteostasis.
2026-08-31
In this open-label, single-arm, phase 1 GlutaPanc trial, Gong and colleagues report the safety and feasibility of l-glutamine in participants with advanced pancreatic ductal adenocarcinoma and determine the recommended phase 2 dose of l-glutamine in combination with gemcitabine and nab-paclitaxel.
2026-08-31
Kim et al. present cryo-EM structures of GluN1–GluN3A NMDA receptors with complementary electrophysiology, revealing structure-based mechanisms of receptor gating, paradoxical potentiation by a GluN1-selective antagonist and allosteric modulation.
2026-08-28
This study uses genomic structural equation modeling to analyze genetic relationships between major depressive disorder and physical disease comorbidities and identifies independent loci associated with their shared genetic liability.
2026-08-26
Chen and colleagues report that the neuropeptide galanin impairs antitumor immunity in glioblastoma by interacting with its receptor GALR3 on monocytic myeloid-derived suppressor cells, promoting their infiltration and ferroptosis resistance.
2026-08-25
Researchers at the Land Institute and the HudsonAlpha Institute for Biotechnology have produced the first chromosome-scale, haplotype-phased genome...
2026-08-24
A study (https://www.science.org/doi/10.1126/sciadv.adz5561) published in Science Advances by researchers at the University of Vienna maps how genome...
2026-08-20
Aging is a major risk factor for many diseases, but reliable methods for measuring how quickly cells age have been lacking. Now, researchers at...
2026-08-18
An unhealed wound leaves a scar. In the genome, an unrepaired DNA lesion leaves a mutation — a permanent edit to the genetic code. Mutations can...
2026-08-13
Scientists at St. Jude Children’s Research Hospital have built a single-cell atlas of V1 interneurons, a key class of spinal neurons involved in...
2026-08-11
