"Познание начинается с удивления" (Аристотель)
Новое в науке на 2026-09-10
Lai et al. show that Nakaseomyces glabratus is enriched in fecal and tumor samples of patients with castration-resistant prostate cancer and that administration of the fungus accelerates cancer progression in prostate cancer-bearing castrated mice.
2026-09-09
Like charges normally repel one another, yet DNA molecules must pair up inside living cells to carry out essential biological processes, including...
2026-09-09
More than two decades after scientists first sequenced the human genome’s 3 billion DNA letters, most of that code’s meaning remains unclear. Only 1...
2026-09-09
The authors present a comprehensive comparative resource for adult human and mouse adrenal glands through single-cell and spatial transcriptomic analyses.
2026-09-08
Single-nucleosome imaging/tracking and super-resolution three-dimensional structured illumination microscopy within euchromatic regions show that cohesin-mediated loops constrain condensed euchromatic domains. Cohesin loss increases their fluidity without affecting their overall compaction, leading to local domain mixing and compromised transcriptional insulation.
2026-09-08
Researchers at the University of East Anglia have identified shared biological mechanisms that may help explain chronic exhaustion in conditions...
2026-09-03
Scientists have long understood that each of the roughly 20,000 genes in the human body carries the instructions for a single kind of protein....
2026-09-02
Proteasomes are essential for male fertility. Kolata, dos Santos, Dendooven and colleagues show large nuclear proteasomal assemblies segregated from DNA in human sperm, forming after meiosis and with a unique α4s isoform. A native substrate is bound at the 20S catalytic site.
2026-09-01
Kücükköse, Luzarowski and colleagues show that removing a single N-terminal amino acid during the maturation of newly imported mitochondrial proteins globally stabilizes mitochondrial protein complexes, revealing an unexpected layer of regulation of mitochondrial proteostasis.
2026-08-31
In this open-label, single-arm, phase 1 GlutaPanc trial, Gong and colleagues report the safety and feasibility of l-glutamine in participants with advanced pancreatic ductal adenocarcinoma and determine the recommended phase 2 dose of l-glutamine in combination with gemcitabine and nab-paclitaxel.
2026-08-31
Kim et al. present cryo-EM structures of GluN1–GluN3A NMDA receptors with complementary electrophysiology, revealing structure-based mechanisms of receptor gating, paradoxical potentiation by a GluN1-selective antagonist and allosteric modulation.
2026-08-28
Chen and colleagues report that the neuropeptide galanin impairs antitumor immunity in glioblastoma by interacting with its receptor GALR3 on monocytic myeloid-derived suppressor cells, promoting their infiltration and ferroptosis resistance.
2026-08-25
Researchers at the Land Institute and the HudsonAlpha Institute for Biotechnology have produced the first chromosome-scale, haplotype-phased genome...
2026-08-24
