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"Жизнь коротка, наука -- бесконечна" (Гиппократ)
Новое в науке на 2026-07-12

Evolving patterns of co-mutations from tumor initiation to metastatic progression

SelectSim uses cancer and healthy tissue sequencing datasets to identify co-mutations that occur more or less frequently than would be expected by chance. Differences in co-mutation patterns observed during different stages of tumor evolution are also explored.

2026-07-10

Multiscale analysis and functional validation of the cellular and genetic determinants of skeletal disease

The study integrates cross-species single-cell and genomic analyses with functional validations to map the endosteal bone compartment, revealing musculoskeletal-disease-relevant cell types and transcriptional programs.

2026-07-10

New Analysis Splits Leukemia Into 16 Epigenomic Subgroups

Acute myeloid leukemia (AML) is one of the most aggressive of all blood cancers, and how it is classified helps determine how each patient is...

2026-07-09

Genome-Wide CRISPR Screen Uncovers Unlikely Psoriasis Target

Biohub researchers performed what they believe is the first genome-wide CRISPR study of primary human adult skin cells, then used an AI model to mine...

2026-07-08

Engineered Protein Motor Takes Its First Steps Along DNA Track

An international team led by Lund University and the University of New South Wales has built an artificial protein motor that takes controlled,...

2026-07-07

Promoter reinforcement supports transcriptional resilience in drug-resistant cancer

Kameswaran et al. show that cancer cells can restore gene expression after TEAD inhibition by shifting control from enhancers to promoters, a process termed ‘promoter reinforcement’, enabling transcription despite disrupted promoter–enhancer communication.

2026-07-06

High-Resolution Sequencing Exposes Hidden Toxoplasma Diversity

An international research team has used high-resolution sequencing to reveal previously hidden genetic diversity in Toxoplasma gondii. The study,...

2026-07-02

IDH1-mutant vaccine in newly diagnosed astrocytoma: final analysis of the multicenter, single-arm, open-label, first-in-human phase 1 NOA16 trial

In the multicenter, single-arm, open-label, first-in-human phase 1 NOA16 trial, Platten and colleagues report the long-term clinical and immunological follow-up outcomes of a vaccine targeting mutant IDH1 in persons with astrocytoma.

2026-07-01

New AI Model Captures Long-Range Genomic Signals to Improve RNA Splice Site Prediction

A deep learning model developed at the University of Tokyo can analyze DNA sequences spanning up to 100,000 base pairs to predict RNA splice sites...

2026-06-30